Category Archives: Curcumin and Cancer

Samples of Curcumin Clarifying Its Defense Against Cancer

Many studies have been performed on the various examples of curcumin. They are supplements that have incredible pharmaceutical benefits. A lot of these studies suggest curcumin may be useful for the avoidance and treatment of numerous diseases.

A great example is curcumin’s use within oncology, in Weill Medical College and in New York Presbyterian Hospital. It is noted that curcumin, which is a curcuminoid originating in turmeric, directly repressed the COX-2 enzyme according to Zhang et al. 1999. Many different oncologists are extremely excited about curcumin being such a effective anti-inflammatory substance. It is classified as a prospective third generation chemo-preventive agent with regard to cancer.

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Curcumin is illustrative of its defense towards cancer, is its capability of suppressing chemically stimulate carcinogenesis in the colon, while being administered from various stages of cancer development. When laboratory rats got curcumin at an initial stage or perhaps delayed and given in the actual premalignant phase, the rats were built with a smaller occurrence and less figures of all-encompassing malignant tumors with the colon. (Kawamori et al. 1999). Also, as a result of curbing the acid interactions of COX-2-arachidonic, curcumin curbs prostaglandins which are the reason for inflammatory progressions. (Plummer et al. 1999). Continual inflammation continues to be considered as a reason for having colon cancer, for many years. (Konig et al. 1976).

Examples of curcumin healing inside antioxidant action are the slowing down, or even reversing of the oxidative damage. It can this by searching for and counteracting the free radicals. By resolving the superoxide and hydroxyl radicals and the infringement on the oxidative chain, it causes these kinds of reactions. Curcumin shields DNA with exceptional efficiency over Vitamin E, beta-carotene or lipoic acid (Ruby et al. 1995; Li et al. 2001; Ahsan et al. 1999).

More examples deal with breast cancer. Curcumin inhibits the increase of various cell traces of breast cancer (Inano et al. 1999), mainly the ones that are a consequence of environmental contact with chemical and pesticide estrogens (Verma et al. 1998). In addition, oestrogen, curcumin, and estrogen impersonators get entry to the cells by way of the aryl hydrocarbon receptor. Since curcumin contends for entry, it can assist in populating out the harmful materials (Ciolino et al. 1998).

From concentrations as small as 3.5 mcg/mL, curcumin provoked apoptotic cell dying in promyelocytic leukemia HL-60 cells (Kuo et al. 1996).

Studies have shown examples of curcumin helping together with prostate cancer. Curcumin has the ability to diminish the actual proliferative prospect of androgen-independent cancer cells in the prostate related, plus cells of additional androgen-dependent cancers. This is done usually by the encouragement of apoptosis. Moreover, a considerable decline in microvessel density, which is the supporting blood supply of tumors, had been observed (Dorai et al. 2001).

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